General Information

  • ID:  hor003896
  • Uniprot ID:  P06297
  • Protein name:  Corticotropin
  • Gene name:  pomc
  • Organism:  Oryctolagus cuniculus (Rabbit)
  • Family:  POMC family
  • Source:  Animal
  • Expression:  Expressed in the pituitary gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SYSMEHFRWGKPVGKKRRPVKVYPNGAENESAEAFPVEV
  • Length:  39(1-39)
  • Propeptide:  SYSMEHFRWGKPVGKKRRPVKVYPNGAENESAEAFPVEV
  • Signal peptide:  NA
  • Modification:  T1 N-acetylserine;T13 Valine amide;T31 Phosphoserine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the adrenal glands to release cortisol.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  MC4R, MC3R
  • Target Unid:  G1TZU3, G1TLF3
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P06297-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P06297-F1.pdbhor003896_AF2.pdbhor003896_ESM.pdb

Physical Information

Mass: 515600 Formula: C202H307N57O57S
Absent amino acids: CDILQT Common amino acids: EV
pI: 9.81 Basic residues: 8
Polar residues: 10 Hydrophobic residues: 11
Hydrophobicity: -93.33 Boman Index: -9034
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 44.87
Instability Index: 5367.69 Extinction Coefficient cystines: 8480
Absorbance 280nm: 223.16

Literature

  • PubMed ID:  3013598
  • Title:  Isolation, characterization, and corticotropic activity of rabbit adrenocorticotropin.